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When cisplatin enters renal tubular epithelial cells, BAX translocates to mitochondria and activates caspase-2, resulting in the release of cytochrome c , second mitochondria-derived activator of caspase/direct inhibitor of apoptosis proteins binding protein with low Pi (isoelectric point) (SMAC/DIABLO), high temperature requirement A2 (HtrA2/Omi), and apoptosis-inducing factor (AIF) from mitochondria [34]

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