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Upon docking Inhibitor 1 into the active sites of these enzymes based on the previously determined structures of the Inhibitor 2- and Inhibitor 3-bound Ec GUS complexes (PDB: 3LPF and 3LPG, respectively) and the UNC10201652-bound Cp GUS complex, we observed that F365 present on the Loop 1 of the adjacent Ec GUS monomer likely serves as a primarily contact with Inhibitor 1, as previously described (Fig

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When there's one big trial that fails, the funding just completely dries up