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Key priorities include (i) defining the spatiotemporal regulation of ferroptosis within heterogeneous TMEs (ii) identifying organelle-specific sites of action and dominant directions of crosstalk (iii) clarifying the context-dependent regulatory logic linking ferroptosis with immune and metabolic programs (iv) developing high-specificity biomarkers for patient stratification (v) establishing mechanism-based combination strategies that integrate conventional therapies with emerging modalities (vi) and creating imaging tools and in vivo readout systems capable of monitoring ferroptosis activity in real time

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