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4.1 Risks of supplement use during chemotherapy The use of natural remedies during chemotherapy in breast cancer is a compound scenario that includes the safety issue as well as drug–supplement interferences and merits meticulous assessment, because these interventions—usually considered as harmless substances—may significantly alter the pharmacokinetic/pharmacodynamic response, antitumoural activity, and toxicity profile to conventional oncologic treatment (200)

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[DOI] [PubMed] [Google Scholar] 508.Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, Woods A, Robinson IC, Schuster E, Batterham RL, Kozma SC, Thomas G, Carling D, Okkenhaug K, Thornton JM, Partridge L, Gems D, Withers DJ