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Based on expert consensus guidelines, developed and maintained by the Clinical Pharmacogenetics Implementation Consortium and the International Society of Psychiatric Genetics, 4 of these CYP450 isoenzymes are “clinically actionable” through PPGx testing (CYP2B6, 2C9, 2C19, and 2D6), as shown in 7-9 CYP450 Genetic Polymorphisms Determine Isoenzyme Activity There is a wide range of in vivo activity for each CYP450 isoenzyme, based on the effects of various nucleic acid mutations on the final gene product

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