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Subsequently, studies revealed that p53 inhibitor obviously decreased P53 protein expression induced by GRh3 as well as NRF2 nuclear translocation

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Since a substantial portion of dAGEs in food is bound to proteins, this suggests that proteolytic digestion may play a role in their breakdown and some human digestive enzymes, such as elastase, trypsin, and chymotrypsin, are likely to contribute to the degradation of protein-bound dAGEs (105–107)

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