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113 , 114 Due to their unique physicochemical properties and highly tunable natures, nanomaterials have been explored in biomedical fields, such as drug delivery, diagnosis, and disease therapy.115, 116, 117 Although DFO has been shown as a highly effective iron chelator in chelating iron, it has a poor oral bio-availability with a short half-life (20–30 min in humans) to limit its routine use (subcutaneous or intravenous administrations at a dose of 20–50 mg/kg/day for 8–24 h, 5 days a week)