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On the other hand, clinical data suggest a high analgesic efficacy after intra-articular administration: as many as 87.5% of patients with knee pain experienced improvement following BPC-157 treatment, both as monotherapy and in combination with thymosin beta 4 (TB4) [201,202]
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In addition, anorexia, gastroparesis, slow intestinal transit or diarrhea, increased gut mucosal permeability and gut microbiota impairment may represent worsening factors [31,32]
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