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a moderate calorie restriction diet is recommended, as this provides for better patient compliance and better long-term outcomes since subjects do not have to adhere to austere, aggressive diets, e.g., aggressive caloric restriction diets

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On the other hand, NAC can suppress osteoclastogenesis by reducing ROS level in LPS-induced inflammatory microenvironment, consequently attenuating osteolysis (Yan et al., 2020)