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Like all B Complex vitamins, Thiamine is water soluble, so it is rapidly absorbed and excreted from the body, and requires regular supplementation, especially in hard working animals when dietary input will probably not be sufficient

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96 In addition, repeated lung injury inhibits the expression of chemokine receptor CXCR7 on lung capillary endothelial cells (PCECs) and recruits VEGFR1 + perivascular macrophages, causing excessive activation of the Wnt/β-catenin pathway in PCECs